What, with all the attacks on science and scientist these days, we may not want to be focusing on those times when science goes off the rails and makes a huge mess of things. But, science at its best and scientists at their best, will never shy away from such things.

Dr. Paul Offit just wrote a book called Pandora’s Lab: Seven Stories of Science Gone Wrong, which not about an evil black dog that escaped from a box, but rather, seven instances when the march of scientific progress headed off a cliff rather than in the desired direction. People died. Many people died. Other bad things happened.

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Note: I interviewed Paul Offit about his book on Atheist Talk Radio. This interview will be aired on Sunday, May 28th, and will be available as a podcast. It should be HERE.
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Readers will have different reactions to, and ways to relate to, each of the seven different stories, because they are far flung and cover a great deal of time, diverse social settings, and a wide range of scientific endeavors. Some readers will get mad because he talks about DDT and Rachel Carson, though I assure you his argument is mostly reasonable (I did disagree with some parts). All readers will be amazed at the poppy plant and all it can do and has done, and astonished at the immense apparent ignorance displayed by that plant’s exploiters, from back in the early 19th century to, well, yesterday. Those interested in race and racism, the use of poison gas to kill people, will find things you didn’t know in Offit’s carefully researched histories. Also, don’t forget to take your vitamins. Or, maybe, forget to take your vitamins.

The chapter “The Great Margarine Mistake” is a great example of the very commonly screwed up interface between food science, food production and marketing, and the shaping of food preference among regular people. You know, that thing where “They tell us not to drink coffee. Then they tell us to drink coffee. They don’t know nothin'”

My biggest disagreement with Paul is over malaria. He did not incorporate an often overlooked fact about the disease into his discussion, and had he done so, may have written a somewhat different chapter. Briefly, in zones where there are two wet seasons (or one long wet season and a very short dry season) there has never really been success in curtailing malaria. In zones where there is a very long dry season but it is wet enough for part of the year for the mosquito that carries malaria to exist at least most years, malaria is relatively easy to beat down using a wide range of techniques, no one of which is supreme. So, for example, today, the distribution of malaria in South Africa, where it is not actually that common (thousands of cases in a normal year among tens of millions of people) is determined mainly by how wet the eastern wet season is, integrated with the movement into that area of people, usually refugees, who are a) infected and b) not getting medical treatment. (See this.)

Malaria was wiped out in country after country prior to the use of DDT, then the DDT came in and helped a great deal, in those relatively dry countries. But the wet countries, not so much. Indeed, in a place like Zaire, there are absolutely no reliable statistics on how common Malaria is or ever was over most of the country, but when I lived there in the 1980s, it was as common as the common cold in New Jersey, and DDT was theoretically in use. (That is a second correlation with causation: the wetter the equatorial country, the less we actually know about disease. I recall leaving the deep rain forest to visit the “city” to get hold of a few courses of leprosy medicine for a handful of people who visited our clinic who had it, where I had dinner with a guy from the UN who was on his victory lap for having wiped out leprosy in Africa.)

In some ways, Offit’s final chapter is the most interesting, the eighth chapter (combined with the Epilog) in which he does two things. One is to identify the kind of reasoning mistake, or methodological mistake, each of his seven examples exemplifies. Such as failure to pay attention to the data, or failure to pay attention to the man behind the curtain. The other is to go quickly through what may end up being similar stories of science gone wrong just starting to brew today or in recent decades, such as the long term unintended effects of widespread use of antibiotics.

A question that Offit’s book raises, indirectly, is this: When a Pandora-like box opens and some sort of monster creeps out, why did the box open to begin with? Sometimes it is jostled open, like in the case of unintended negative outcomes from the use of antibiotics. Sometimes it is opened because someone can’t resist the treasures that may be inside. Sometimes it is opened because science is an open process and must always seek knowledge etc. etc. I wonder if the recent development of an engineered polio virus (three instances), or the Spanish Flu, is an example of such. Sometimes it is opened because of (Godwin Warning!) HITLER. Seriously.

I don’t know what knowing these reasons gets us, but one possibility is this: when we find ignorance as a root cause of calamity, perhaps an appreciation of knowledge is gained. That is certainly the lesson of Offit’s review of the products of opium, their invention, intensification, deployment, and use. Apparently addiction was simply not understood at all until fairly recently, and that lack of understanding caused science, medical technology, and medical practice to do the exactly wrong thing over and over again.

And of course, lobotomies. The invention of the latter method of doing this useless and horrible procedure is something that, if put in a movie as a plot element, would kill the movie because it is not possible to suspend disbelief to the degree necessary to stay seated in the theater.

Pandora’s Lab: Seven Stories of Science Gone Wrong is a great read and a necessary addition to the bookshelf of any practicing skeptic or science enthusiast.

Paul Offit, who is a pediatrician and the inventor of a rotavirus vaccine (see this for an interesting podcast on a related topic), is the Maurice R. Hilleman Professor of Vaccinology and Professor of Pediatrics at the Perelman School of Medicine, University of Pennsylvania. He is also chief of Infectious Diseases and director of Vaccine Education at the Children’s Hospital of Philadelphia.

Aside from Pandra’s Lab, he also wrote Do You Believe in Magic?: Vitamins, Supplements, and All Things Natural: A Look Behind the Curtain, Deadly Choices: How the Anti-Vaccine Movement Threatens Us All, and Bad Faith: When Religious Belief Undermines Modern Medicine.