Tag Archives: Beer

Can an extract from hops flowers reduce breast cancer risk?

Some sort of Hops Flowers Substance is a common dietary supplement used by post-menopausal women. A recent study looks at one molecule extracted from hops to see if it could help reduce the chance of getting breast cancer.

The paper is in the journal Chemical Research in Toxicology, and is called Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation, by Shuai Wang, Tareisha L. Dunlap, Caitlin E. Howell, Obinna C. Mbachu, Emily A. Rue, Rasika Phansalkar, Shao-Nong Chen, Guido F. Pauli, Birgit M. Dietz, and Judy L. Bolton.

One factor that increases the risk of breast cancer is exposure to estrogen, which may be the result of hormone treatment in post-menopausal women (hormone replacement therapy, or HRT). The “natural supplement” made from hops is supposed to supply plant-originated hormones that, perhaps, are believed by some to be less likely to have bad side effects. I’m pretty sure there is no reason to think that. It might be, however, that a molecule found in hops extract, taken to supply phyotestrogen (as a “natural” alternative to industrially produced estrogen) could independently reduce breast cancer risk. This research is still in early stages.

From the press release that goes along with the paper:

Preliminary lab studies have suggested that certain active compounds from hops could have protective properties. Building on this lead, Judy L. Bolton and colleagues used an enriched hop extract to test its effects on estrogen metabolism, one of the processes in the development of breast cancer.

The researchers applied the extract to two different breast cell lines to see how they would affect estrogen metabolism. One particular hops compound called 6-prenylnaringenin, or 6-PN, boosted the cells’ detoxification pathway that studies have associated with a lower risk for breast cancer. Thus the results suggest that 6-PN could have anti-cancer effects, although more studies would be needed to further investigate this possibility, the researchers say.

I asked Dr. Bolton the obvious question, which I know people will want to know the answer to. “If a woman drinks a LOT of beer, is that going to help avoid breast cancer? And, if so, how much beer?”

Dr. Bolton only had bad news in this regard. She and her team used a byproduct of beer making that concentrated the hops extract, and further concentrated this. (I simplify a bit.) She guesses that the amount of 6-PN in actual beer would be very very low. So, no.

But putting that aside, this research does look promising. An anti-breast cancer dietary supplement that is easy to produce and inexpensive, and that has few or no side effects (other research has failed to show any serious side effects of this stuff) would be a very good thing.

Does drinking beer increase your attractiveness …. to mosquitoes?

ResearchBlogging.orgThe anopheles mosquito, Anopheles gambiae, is the primary vector for human malaria. Mosquitoes in general, the A. gambiae included, find their prey by tracking body odor exuded from the breath and skin. Apparently, the composition of body odor determines A. gambiae‘s preference for one individual over another. It has been known for some time now that A. gambiae preferentially seek out and draw blood from pregnant women (Linsay et al 2000; Ansell et al 2002; Himeidan, Elbashir and Adam 2004), preferring pregnant over none pregnant women at about a 2:1 ratio.


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Beer is fundemental

Back in the 1980s, archaeologists working in the middle east realized one day that the origin of agriculture …. domesticated barley, to be exact … in that region was all about beer. This is because this early barley could not be de-shelled to make flour. The only practical way to consume it was to make beer out of it.That explained a lot of things…Now, there is a report that the origin of chocolate is also all about beer. Continue reading Beer is fundemental