{"id":1661,"date":"2008-03-05T10:11:36","date_gmt":"2008-03-05T10:11:36","guid":{"rendered":"http:\/\/scienceblogs.com\/gregladen\/2008\/03\/05\/costly-placebo-works-better-th\/"},"modified":"2008-03-05T10:11:36","modified_gmt":"2008-03-05T10:11:36","slug":"costly-placebo-works-better-th","status":"publish","type":"post","link":"https:\/\/gregladen.com\/blog\/2008\/03\/05\/costly-placebo-works-better-th\/","title":{"rendered":"Costly Placebo Works Better Than Cheap One"},"content":{"rendered":"<p>Given two pills, one that costs ten cents and the other that cost $2.50, with both being simple sugar pills with no possible medical benefit, the more expensive pill works better to ameliorate certain conditions.  I&#8217;m sure that the pharmaceutical companies will like this!<!--more--><\/p>\n<blockquote><p>Durham, NC &#8212; A 10-cent pill doesn&#8217;t kill pain as well as a $2.50 pill, even when they are identical placebos, according to a provocative study by Dan Ariely, a behavioral economist at Duke University.&#8221;Physicians want to think it&#8217;s the medicine and not their enthusiasm about a particular drug that makes a drug more therapeutically effective, but now we really have to worry about the nuances of interaction between patients and physicians,&#8221; said Ariely, whose findings appear as a letter in the March 5 edition of the Journal of the American Medical Association.Ariely and a team of collaborators at the Massachusetts Institute of Technology used a standard protocol for administering light electric shock to participants&#8217; wrists to measure their subjective rating of pain. The 82 study subjects were tested before getting the placebo and after. Half the participants were given a brochure describing the pill as a newly-approved pain-killer which cost $2.50 per dose and half were given a brochure describing it as marked down to 10 cents, without saying why.In the full-price group, 85 percent of subjects experienced a reduction in pain after taking the placebo. In the low-price group, 61 percent said the pain was less.The finding, from a relatively small and simplified experiment, points to a host of larger questions, Ariely said.The results fit with existing data about how people perceive quality and how they anticipate therapeutic effects, he said. But what&#8217;s interesting is the combination of the price-sensitive consumer expectation with the well-known placebo effect of being told a pill works. &#8220;The placebo effect is one of the most fascinating, least harnessed forces in the universe,&#8221; Ariely said.Ariely wonders if prescription medications should offer cues from packaging, rather than coming in indistinguishable brown bottles. &#8220;And how do we give people cheaper medication, or a generic, without them thinking it won&#8217;t work?&#8221; he asks.At the very least, doctors should be able to use their enthusiasm for a medication as part of the therapy, Ariely said. &#8220;They have a huge potential to use these quality cues to be more effective.&#8221;<a href=\"http:\/\/dukenews.duke.edu\/2008\/03\/placeboprice.html\">[source]<\/a><\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Given two pills, one that costs ten cents and the other that cost $2.50, with both being simple sugar pills with no possible medical benefit, the more expensive pill works better to ameliorate certain conditions. I&#8217;m sure that the pharmaceutical companies will like this!<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"1","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[103],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p5fhV1-qN","jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/posts\/1661"}],"collection":[{"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/comments?post=1661"}],"version-history":[{"count":0,"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/posts\/1661\/revisions"}],"wp:attachment":[{"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/media?parent=1661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/categories?post=1661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gregladen.com\/blog\/wp-json\/wp\/v2\/tags?post=1661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}