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	<title>
	Comments on: Environmental  effect implicated in behavioral phenotype in humans	</title>
	<atom:link href="https://gregladen.com/blog/2010/02/10/environmental-effect-implicate/feed/" rel="self" type="application/rss+xml" />
	<link>https://gregladen.com/blog/2010/02/10/environmental-effect-implicate/</link>
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	<lastBuildDate>Thu, 11 Feb 2010 09:58:56 +0000</lastBuildDate>
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		<title>
		By: daedalus2u		</title>
		<link>https://gregladen.com/blog/2010/02/10/environmental-effect-implicate/#comment-514401</link>

		<dc:creator><![CDATA[daedalus2u]]></dc:creator>
		<pubDate>Thu, 11 Feb 2010 09:58:56 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2010/02/10/environmental-effect-implicate/#comment-514401</guid>

					<description><![CDATA[Here is the paper

http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.0901470

This is interesting.  I think that what is happening is a disruption of the normal neurodevelopmental pathways that determine these things based on environment.  An infant in a violent environment needs to be a more violent adult.  The cycle of violence is well known, there must be physiology that mediates the cycle of violence and transduces exposure to violence into a more violent phenotype.  

If phthalates are active in those pathways, then there is no threshold for them to exert an effect.  The pathways are already actively regulating things, that is they are already in the &quot;active range&quot;.  Anything that affects those pathways will affect the outcome.  ]]></description>
			<content:encoded><![CDATA[<p>Here is the paper</p>
<p><a href="http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.0901470" rel="nofollow ugc">http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.0901470</a></p>
<p>This is interesting.  I think that what is happening is a disruption of the normal neurodevelopmental pathways that determine these things based on environment.  An infant in a violent environment needs to be a more violent adult.  The cycle of violence is well known, there must be physiology that mediates the cycle of violence and transduces exposure to violence into a more violent phenotype.  </p>
<p>If phthalates are active in those pathways, then there is no threshold for them to exert an effect.  The pathways are already actively regulating things, that is they are already in the &#8220;active range&#8221;.  Anything that affects those pathways will affect the outcome.  </p>
]]></content:encoded>
		
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		<item>
		<title>
		By: David		</title>
		<link>https://gregladen.com/blog/2010/02/10/environmental-effect-implicate/#comment-514400</link>

		<dc:creator><![CDATA[David]]></dc:creator>
		<pubDate>Thu, 11 Feb 2010 00:41:12 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2010/02/10/environmental-effect-implicate/#comment-514400</guid>

					<description><![CDATA[Doh!  TWIM.  ]]></description>
			<content:encoded><![CDATA[<p>Doh!  TWIM.  </p>
]]></content:encoded>
		
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		<item>
		<title>
		By: Ana		</title>
		<link>https://gregladen.com/blog/2010/02/10/environmental-effect-implicate/#comment-514399</link>

		<dc:creator><![CDATA[Ana]]></dc:creator>
		<pubDate>Wed, 10 Feb 2010 23:48:35 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2010/02/10/environmental-effect-implicate/#comment-514399</guid>

					<description><![CDATA[Read again, David:  &quot;Children were 2.5 times more likely&quot;...]]></description>
			<content:encoded><![CDATA[<p>Read again, David:  &#8220;Children were 2.5 times more likely&#8221;&#8230;</p>
]]></content:encoded>
		
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		<item>
		<title>
		By: David		</title>
		<link>https://gregladen.com/blog/2010/02/10/environmental-effect-implicate/#comment-514398</link>

		<dc:creator><![CDATA[David]]></dc:creator>
		<pubDate>Wed, 10 Feb 2010 20:30:05 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2010/02/10/environmental-effect-implicate/#comment-514398</guid>

					<description><![CDATA[A 2.5 percent increase, which I assume is a hazzards analysis result, is nothing to sneeze at (sorry for the pun!)]]></description>
			<content:encoded><![CDATA[<p>A 2.5 percent increase, which I assume is a hazzards analysis result, is nothing to sneeze at (sorry for the pun!)</p>
]]></content:encoded>
		
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