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	<title>
	Comments on: A dead gene comes back to life in humans	</title>
	<atom:link href="https://gregladen.com/blog/2009/03/09/a-dead-gene-comes-back-to-life/feed/" rel="self" type="application/rss+xml" />
	<link>https://gregladen.com/blog/2009/03/09/a-dead-gene-comes-back-to-life/</link>
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		<title>
		By: jason smith		</title>
		<link>https://gregladen.com/blog/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532285</link>

		<dc:creator><![CDATA[jason smith]]></dc:creator>
		<pubDate>Thu, 05 Aug 2010 03:43:39 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532285</guid>

					<description><![CDATA[it me again and is it illegal!]]></description>
			<content:encoded><![CDATA[<p>it me again and is it illegal!</p>
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		<title>
		By: jason smith		</title>
		<link>https://gregladen.com/blog/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532284</link>

		<dc:creator><![CDATA[jason smith]]></dc:creator>
		<pubDate>Thu, 05 Aug 2010 03:40:24 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532284</guid>

					<description><![CDATA[i wana bring the dead back to life and i need your help.    can you show me the steps and if it worked. would the zombie try to eat me or is there a way that you can do show the zombie can at other stuff like plants or something?       ]]></description>
			<content:encoded><![CDATA[<p>i wana bring the dead back to life and i need your help.    can you show me the steps and if it worked. would the zombie try to eat me or is there a way that you can do show the zombie can at other stuff like plants or something?       </p>
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		<title>
		By: AK		</title>
		<link>https://gregladen.com/blog/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532283</link>

		<dc:creator><![CDATA[AK]]></dc:creator>
		<pubDate>Tue, 10 Mar 2009 11:06:09 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532283</guid>

					<description><![CDATA[Some comments re &quot;&lt;i&gt;Junk DNA&lt;/i&gt;&quot;:

When it&#039;s reasonably close to a functioning gene (coding DNA), such random/pseudo-random sequences always have the potential to mutate into a sequence that some transcription factor recognizes.

Any &quot;&lt;i&gt;Junk DNA&lt;/i&gt;&quot; between a transcription recognition sequence and the promoter sequence can change its length, with potential impact on the transcription rates relative to transcription factor concentrations.

A large proportion of &quot;&lt;i&gt;Junk DNA&lt;/i&gt;&quot; improves the chance that a random insertion of some sequence (such as a new copy of a functioning gene) will land safely, without disrupting any existing gene/control system.

&quot;&lt;i&gt;Pseudogene&lt;/i&gt;&quot; is probably as good a term as any for a copy of the coding sequence(s) without the associated promoter and other control sequences.  (Of course it would also apply to a copy of both in which the control sequences had mutated to turn them off.)

We should remember that the DNA repair system uses an available copy of a similar sequence to repair breaks:  if a break in an active sequence is repaired using a &quot;&lt;i&gt;Pseudogene&lt;/i&gt;&quot;, the accumulated mutations could be added to the active sequence in a package.  This, in addition to the re-activation of a &quot;dead&quot; pseudogene, has the potential to &quot;jump over&quot; poor fitness landscapes of individual mutations to land on a beneficial package of such mutations.  Of the two processes above, I suspect the first is much more common.]]></description>
			<content:encoded><![CDATA[<p>Some comments re &#8220;<i>Junk DNA</i>&#8220;:</p>
<p>When it&#8217;s reasonably close to a functioning gene (coding DNA), such random/pseudo-random sequences always have the potential to mutate into a sequence that some transcription factor recognizes.</p>
<p>Any &#8220;<i>Junk DNA</i>&#8221; between a transcription recognition sequence and the promoter sequence can change its length, with potential impact on the transcription rates relative to transcription factor concentrations.</p>
<p>A large proportion of &#8220;<i>Junk DNA</i>&#8221; improves the chance that a random insertion of some sequence (such as a new copy of a functioning gene) will land safely, without disrupting any existing gene/control system.</p>
<p>&#8220;<i>Pseudogene</i>&#8221; is probably as good a term as any for a copy of the coding sequence(s) without the associated promoter and other control sequences.  (Of course it would also apply to a copy of both in which the control sequences had mutated to turn them off.)</p>
<p>We should remember that the DNA repair system uses an available copy of a similar sequence to repair breaks:  if a break in an active sequence is repaired using a &#8220;<i>Pseudogene</i>&#8220;, the accumulated mutations could be added to the active sequence in a package.  This, in addition to the re-activation of a &#8220;dead&#8221; pseudogene, has the potential to &#8220;jump over&#8221; poor fitness landscapes of individual mutations to land on a beneficial package of such mutations.  Of the two processes above, I suspect the first is much more common.</p>
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		<title>
		By: ppnl		</title>
		<link>https://gregladen.com/blog/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532282</link>

		<dc:creator><![CDATA[ppnl]]></dc:creator>
		<pubDate>Tue, 10 Mar 2009 10:06:33 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532282</guid>

					<description><![CDATA[

I have always wondered if the vitamin c gene could be repaired in humans.  ]]></description>
			<content:encoded><![CDATA[<p>I have always wondered if the vitamin c gene could be repaired in humans.  </p>
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		<title>
		By: Laurent		</title>
		<link>https://gregladen.com/blog/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532281</link>

		<dc:creator><![CDATA[Laurent]]></dc:creator>
		<pubDate>Tue, 10 Mar 2009 09:36:35 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532281</guid>

					<description><![CDATA[&quot;They Jus&#039; gene&quot;?]]></description>
			<content:encoded><![CDATA[<p>&#8220;They Jus&#8217; gene&#8221;?</p>
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		<title>
		By: rcn2		</title>
		<link>https://gregladen.com/blog/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532280</link>

		<dc:creator><![CDATA[rcn2]]></dc:creator>
		<pubDate>Tue, 10 Mar 2009 01:59:33 +0000</pubDate>
		<guid isPermaLink="false">http://scienceblogs.com/gregladen/2009/03/09/a-dead-gene-comes-back-to-life/#comment-532280</guid>

					<description><![CDATA[So, like, you have genes that get turned off and &#039;buried&#039; in the genome.  Pseudogenes.

Which then come back to life.  Or resurrected.

I henceforth name these genes &quot;Jesus Genes!&quot;

(I was going to go for &quot;Zombie Genes&quot;, but I liked the alliteration.)]]></description>
			<content:encoded><![CDATA[<p>So, like, you have genes that get turned off and &#8216;buried&#8217; in the genome.  Pseudogenes.</p>
<p>Which then come back to life.  Or resurrected.</p>
<p>I henceforth name these genes &#8220;Jesus Genes!&#8221;</p>
<p>(I was going to go for &#8220;Zombie Genes&#8221;, but I liked the alliteration.)</p>
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